Shanghai Pemichem Lab Supply Raw Materials Pharmaceutical Intermediates Powderchloro Quine Diphosphate CAS 50-63-5 API with 99% Pruity

• CAS No.: 50-63-5
• Formula: 50-63-5
• EINECS: 200-055-2
• Model NO.: TAPI-701
• Classification: Organic Analytical Reagents
• Grade: GR
• Content: Standard
• Usage: Laboratory Reagents
• Source: Concrete
• Habit Appellation: Fine Chemicals
• Application: Scientific Research
• Property: Organic Reagent
• MW: 515.86
• Transport Package: Penicillin Bottle, Aluminium Foil Bag
• Specification: 1g, 100g
• Origin: Shanghai
• Production Capacity: 5000kg/Year

Product Description

1.For some materials, we could supply free Samples for testing at first..
2.MOQ: 1g or 5g
3.More than 3000 kinds of materials in stock.
4.More than 11+ manufacturing experience.
5.Certification: MSDS,HALAL,COA,IFRA,ISO9001, ISO22000,26 Allergens, etc.
6.Lead time:about 8-12 working days.
8.Verified by Made-in-China as Golden Supplier.
9.We will reply you for your inquiry in 24 hours.
10. Our Q&C team will inspect every product quality strictly before delivery.

What is CAS 50-63-5 Chloro quine diphosphate Powder? 
          

 

Product Name:	Chlor oquine diphosphate
Synonyms:	7-chlor-4-(4-(diaethylamino)-1-methylbutylamino)-chinolindiphosphat;ARALEN PHOSPHATE;CHLOR OQUINE DIPHOSPHATE;CHL OROQUINE DIPHOSPHATE SALT;CHLOROQ UINE PHOSPHATE;7-CHLORO-4-OXO-1H-QUINOLINE-3-CARBOXYLIC ACID;CHLOROQU INE PHOSPHATE BP;CHLOROQ UINE PHOSPHATE BP98
CAS:	50-63-5
MF:	C18H32ClN3O8P2
MW:	515.86
EINECS:	200-055-2
Product Categories:	Inhibitors;ARALEN;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Enzyme;API;50-63-5;Coronavirus
Mol File:	50-63-5.mol

Chlo roquine is an aminoquinoline that is an inhibitor of autophagy and has antimalarial, anti-inflammatory, anticancer, and antiviral activities. Chlo roquine inhibits autophagosome-lysosome fusion in HeLa cells when used at a concentration of 100 μM. It is active against the chloro quine-sensitive GC03 strain of P. falciparum (IC₅₀ = 29.2 nM) but has decreased activity against mutant pfcrt P. falciparum (IC₅₀s = 100-150 nM). Chloroqui ne prevents infection by severe acute respiratory coronavirus 2 (SARS-Co V-2) in Vero cells (EC₅₀ = 1.13 μM) but does not inhibit SAR -CoV replication in the lungs in a mouse model of S ARS-CoV infection. It inhibits the growth of human SSC25 and CAL 27 oral squamous cell carcinoma cells (IC₅₀s = 29.9 and 17.3 μM, respectively), as well as A498, SN12C, RXF 393, and 769-P renal cancer cells (IC₅₀s = 16, 62, 81, and 25 μM, respectively). It reduces tumor growth in a CAL 27 mouse xenograft model and a 4T1 mouse allograft model when administered at a dose of 50 mg/kg. Formulations containing chloro quine have been used in the prevention of malaria, as well as the treatment of rheumatoid arthritis and systemic lupus erythematosus (SLE), and have been associated with cardiotoxicity and myopathy.

1.Chloroqu ine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. Chlo roquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 μM.

2. Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ.

3. Antimalarial, antiamebic, antirheumatic, intercalating agent

4. An antimalarial compound
 

 

 

 

 

 

 

 

 

 

ShangHai Pemichem is one of professional company specialized in research, development, custom manufacturing and trading of pharmaceutical API, advanced intermediates, Cosmetic raw materials, health and new raw materials, polypeptides, animal drug and organic reagent  etc. 
You can select more than 2000 kinds of raw ingredients here. And we are keeping developing new products and continuously marketing them for sale. You will save lots of time , energy, money and have a very pleasant cooperation with us!
Our purpose: Trransaction is not the end, but the satarting of service!


 

Q&A

1.How could l get a sample?
Before we received the first order, please afford the sample cost and express fee. We will return the sample cost back to you within your first order.

2.Can you make designs for us?
We have a professional design team to help our customers do design work.Both OEM and ODM    orders are accepted.


3.Whether you could make our brand on your products?
Yes. We can print your Logo on both the products and the packages if you can meet our MOQ.

4.How can you provide us high quality products?
We have a professional QC team, every product is shipped after strictly examination.

5.What is your lead time?
7-15days, We will update you eact two-three days!

6.What is your payment?
We accept T/T.L/C.Paypal.Westem union or to be negotiated.Don't worry about anything, if you have      any problems, please feel free to contact us