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What is CAS 23593-75-1 Clotrimaz ole Powder?
Product Name: |
Clotrimazo le |
Synonyms: |
myclo;(2-Chlorophenyl)diphenyl-1-imidazolylmethane;(Chlorotrityl)imida zole;1-((2-chlorophenyl)diphenylmethyl)-1h-imidazol;1-(alpha-(2-Chlorophenyl)benzhydryl)imidaz ole;1-(o-chloro-alpha,alpha-diphenylbenzyl)-imidazol;1-[(2-chlorophenyl)diphenylmethyl]-1h-imidazol;1-(o-Chloro-α,α-diphenylbenzyl)imidazo le |
CAS: |
23593-75-1 |
MF: |
C22H17ClN2 |
MW: |
344.84 |
EINECS: |
245-764-8 |
Product Categories: |
raw material;API;Potassium channel;Aromatics;MYCELEX;Broad-spectrum antifungal drugs;Pharmaceutical Intermediates;Active Pharmaceutical Ingredients;API's;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;23593-75-1 |
Mol File: |
23593-75-1.mol |
Clotrimaz ole is an artificially synthetic a zole antifungal agent with inhibitory effect on a variety of pathogenic fungi. It is also able to directly kill the fungi at high concentration. Clotrimazo le, through interfering with cytochrome P450 activity, inhibits the biosynthesis of the fungal ergosterol and other steroids; cause damage of the fungal cell membrane and change its permeability, causing the leakage of many kinds of important material in the cell; it can also inhibit the biosynthesis of the fungal triglyceride and phosphor-lipid; the product can still inhibit the activity of oxidase and peroxidase, causing the over-accumulation of peroxides in the cell, causing the degeneration and necrosis of the fungal subcellular structures. Clotrimaz ole has broad-spectrum antifungal activity with excellent anti-fungal activity against Epidermophyton, Trichophyton, aspergillosis, coloring fungi, Cryptococcus and Candida species. It also has certain antifungal effect against sporothrix schenckii,blastomycosis dermatitidis, Blastomyces coccidioides as well as Histoplasma.
An antifungal compound and CYP inhibitor.
Clotrimazo le (Lotrimin, Mycelex, etc.) is a synthetic imida zole agent. It acts by altering cell membrane permeability. It inhibits the growth of most dermatophyte species, yeast and Malassezia furfur.
Clotrimazo le formally also is an imidaz ole derivative because of the presence of an imidazo le ring in its structure. It is believed that, like mico naz ole, econazo le, and other "pure" representatives of the imidazol e class, it also inhibits the biosynthesis of ergosterin in the cytoplasmatic membrane of fungi.
In terms of pharmacological action, clotrimazol e is very similar to mic onaz ole. It has a broad spectrum of antifungal activity. It is effective with respect to dermatophytes, and it also has an antimicrobial effect against streptococci and staphylococci. It is also effective with respect to trichomonases. It is very widely used, both externally and vaginally for treating superficial infections. Synonyms of this drug are canesten, empecid, lotrimin, micosporin, and others.
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