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What is CAS 183319-69-9 Erlotinib hydrochloride Powder?
Product Name: |
Erlotinib hydrochloride |
Synonyms: |
ERLOTINIB HCL;ERLOTINIB HCL SALT;ERLOTINIB HCL SALT :TARCEVA;Erlotinib, Hydrochloride Salt;N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva;N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine;[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine;Tarceva HydrochlorideSee E625000 |
CAS: |
183319-69-9 |
MF: |
C22H24ClN3O4 |
MW: |
429.9 |
EINECS: |
620-491-0 |
Product Categories: |
Heterocycles;Intermediates & Fine Chemicals;Heterocyclic Compounds;anti-neoplastic;Pharmaceuticals;Anti-cancer&immunity;API;Molecular Targeted Antineoplastic;Tarceva;Antineoplastic;Inhibitors;183319-69-9 |
Mol File: |
183319-69-9.mol |
1. Erlotinib hydrochlorate is a small molecule tyrosine kinase inhibitor which acts reversibly on epidermal gro wth factor receptors, a hydrochloride of erlotinib, a molecular-targeted drug. The US Food and Drug Administration (FDA) has approved erlotinib (Tarceva) combined with gemcita bine as a first-line treatment for locally advanced and metastatic pancreatic cancer.
It is mainly used as a second- or third-line treatment for locally advanced or metstatic non-small cell lung cancer (NSCLC) and as a treatment for pancreatic cancer. It is used as a tyrosine inhibitor for NSCLC treatment.
2. Erlotinib hydrochloride (V), a quinazoline derived small molecule inhibitor of epidermal grow th factor receptor (EDGFR) tyrosine kinase, was approved in November, 2004, for the treatment of advanced or metastatic non-smallcell lung cancer. It belongs to the same class as gefi tinib,another quinazoline approved for treatment of advanced lung cancer, but with improved pharmacokinetic properties. The molecule was originated by Pfizer and development initiated in collaboration with OSI, which assumed full rights to the drug when Pfizer merged with Warner Lambert. Subsequently, Genentech/Roche went into licensing agreement with OSI to develop and market the drug in the US and Worldwide.
3. Selective epidermal grow th factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic
4. Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Phase 3.
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