Shanghai Pemichem Lab Supply Raw Materials Pharmaceutical Intermediates Powder Tpx-0005 CAS 1802220-02-5 API with 99% Pruity

• CAS No.: 1802220-02-5
• Formula: C18h18fn5o2
• EINECS: 125-417-3
• Model NO.: Pemi-0372
• Classification: Pharmaceutical Grade
• Grade: GR
• Content: Standard
• Usage: Laboratory Reagents
• Source: Concrete
• Habit Appellation: Fine Chemicals
• Application: Scientific Research
• Property: Organic Reagent
• MW: 355.37
• Transport Package: Penicillin Bottle, Aluminium Foil Bag
• Specification: 1g, 100g
• Origin: Shanghai
• Production Capacity: 5000kg/Year

Product Description

1.For some materials, we could supply free Samples for testing at first..
2.MOQ: 1g or 5g
3.More than 3000 kinds of materials in stock.
4.More than 11+ manufacturing experience.
5.Certification: MSDS,HALAL,COA,IFRA,ISO9001, ISO22000,26 Allergens, etc.
6.Lead time:about 8-12 working days.
8.Verified by Made-in-China as Golden Supplier.
9.We will reply you for your inquiry in 24 hours.
10. Our Q&C team will inspect every product quality strictly before delivery.

What is 1802220-02-5 TPX-0005 Powder? 
 

Product Name:	TPX-0005
Synonyms:	Ropotrectinib;TPX-0005;TPX 0005;TPX0005;CS-2479;Repotrectinib(TPX-005);Repotrectinib;Repotrectinib,TPX-0005;TPX-0005;1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-
CAS:	1802220-02-5
MF:	C18H18FN5O2
MW:	355.37
EINECS:	125-417-3
Product Categories:	API;1802220-02-5
Mol File:	1802220-02-5.mol

 

 1. Ropotrectinib (TPX-0005; TP Therapeutics, San Diego, CA, USA) is a nextgeneration ROS1 inhibitor, a novel three-dimensional macrocyle with a much smaller size (MW <370) than current ROS1 inhibitors. It was specifically designed to overcome resistance mutations. Preclinical studies have shown activity against gatekeeper and solvent mutations, including G2032R, D2033N, L2026M, S1986F/Y, L1951R, and kinases involved in bypass signaling such as focal adhesion kinase, SRC proto-oncogene, and non-receptor tyrosine kinase [102, 103].

2.  Repotrectinib has advantage with central nervous system (CNS) penetration, aimed to target both wide-type (WT) and solvent-front mutations (SFM) kinases and other resistance mutations including ROS1-G2032R and ROS1-D2033N, TRKA-G595R, TRKB-G639R, TRKC-G623R, and ALK-G1202R.

 

 

 

 

 

 

ShangHai Pemichem is one of professional company specialized in research, development, custom manufacturing and trading of pharmaceutical API, advanced intermediates, Cosmetic raw materials, health and new raw materials, polypeptides, animal drug and organic reagent  etc. 
You can select more than 2000 kinds of raw ingredients here. And we are keeping developing new products and continuously marketing them for sale. You will save lots of time , energy, money and have a very pleasant cooperation with us!
Our purpose: Trransaction is not the end, but the satarting of service!


 

Q&A

1.How could l get a sample?
Before we received the first order, please afford the sample cost and express fee. We will return the sample cost back to you within your first order.

2.Can you make designs for us?
We have a professional design team to help our customers do design work.Both OEM and ODM    orders are accepted.


3.Whether you could make our brand on your products?
Yes. We can print your Logo on both the products and the packages if you can meet our MOQ.

4.How can you provide us high quality products?
We have a professional QC team, every product is shipped after strictly examination.

5.What is your lead time?
7-15days, We will update you eact two-three days!

6.What is your payment?
We accept T/T.L/C.Paypal.Westem union or to be negotiated.Don't worry about anything, if you have      any problems, please feel free to contact us