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What is CAS 102518-79-6 (-)-Huperzine A Powder?
Product Name: |
(-)-Huperzine A |
Synonyms: |
Huperzine-A1-5%;(5r-(5-alpha,9-beta,11e))-ydro-7-methyl;5,9-methanocycloocta(b)pyridin-2(1h)-one,5-amino-11-ethylidene-5,6,9,10-tetrah;HUPERIZINE;(-)-HUPERZINE A FROM HUPERZIA SERRATA;HuperziaSerrateP.E120786-18-7/;(5R,9R,E)-5-AMino-11-ethylidene-7-Methyl-5,6,9,10-tetrahydro-5,9-Methanocycloocta[b]pyridin-2(1H)-one;(-)-Huperzine A (HupA) |
CAS: |
102518-79-6 |
MF: |
C15H18N2O |
MW: |
242.32 |
EINECS: |
600-320-6 |
Product Categories: |
Inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Alkaloids;API;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;Nutritional Ingredients;reference substance;102518-79-6 |
Mol File: |
102518-79-6.mol |
Huperzine A is a natural plant alkaloid that extracted from the Chinese medicine Huperzia serrata under the genus Huperzia. It is a potent, revisable and highly selective second generation of acetylcholinesterase inhibitors, with the appearance of yellow to white crystalline powder, and is freely soluble in chlor oform, soluble in me thanol and ethanol, slightly soluble in water, with high lipid solubility. It is a small molecule that can well penetrate the blood brain barrier, and after entering the central nervous, it distributes more in the brain's frontal lobe, temporal lobe, hippocampus and areas that are closely related to learning and memory. It has a strong inhibitory effect on acetylcholinesterase (AchE) at a low dosage, significantly increasing the content of acetylcholine (Ach) in neural synaptic cleft in the distribution area, thus enhancing neuronal excitatory transmission, strengthening the excitement of learning and memory in the brain, thereby with the function of improving cognitive function, enhancing memory retention and promoting memory reproduction. It is currently the most successful development of Alzheimer's disease (senile dementia) drugs.
Huperzine A is a new drug for the treatment of benign memory disorders that can effectively prevent cerebral neurasthenia in the middle-aged and elderly, restore cranial nerve function, and activate cranial neurotransmitters. Huperzine A can not only inhibite the activity of cholinesterase, but also improve cognitive function and ability of learning and memory through a variety of pharmacological mechanisms like effecting the system of free radicals, reducing expression levels of somatostatin, intracellular [Ca2+], glutamic acid content and increase calmodulin (CaM) and calmodulin messenger RNA (CaM mRNA).
Function:
1. Help to repair short-term memory impairment and strengthen brain power
2. Help to focus attention and improve memory
3. Huperzine A is an acetylcholinesterase inhibititor
4. Huperzine A help treatment for diseases characterized by neurodegeneration
5. Huperzine A is also a NMDA receptor antagonist which protects the brain against glutamate induced damage
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