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What is CAS 593-84-0 Guanidine thiocyanate Powder?
| Product Name: |
Guanidine thiocyanate |
| Synonyms: |
GTC;GUANIDINE THIOCYANATE;GUANIDINE HYDROTHIOCYANATE;GUANIDINE ISOTHIOCYANATE;GUANIDINE MONOTHIOCYANATE;GUANIDINE RHODANIDE;GUANIDINIUM THIOCYANATE;GUANIDINIUM ISOTHIOCYANATE |
| CAS: |
593-84-0 |
| MF: |
CH5N3.CHNS |
| MW: |
118.16 |
| EINECS: |
209-812-1 |
| Product Categories: |
bulk;proteinmod;Pharmaceutical Intermediates;Sul phur Derivatives;PP;monomer;593-84-0;BDO |
| Mol File: |
593-84-0.mol |
1. Guanidine thiocyanate is one of the cheapest and easiest to prepare of the guanidine salts. Guanidine Thiocyanate is an ultrapure, molecular biology grade reagent. It is free of detectable nuclease and protease activity and is a strong protein denaturant, as both the guanidinium cation and the thiocyanate anion are chaotropic agents. It is provided in one bottle containing 500 g. It is recommended for isolation of RNA, especially for tissues such as pancreas with high levels of RNase activity. In solution, it is known as guanidinium thiocyanate. Guanidine Thiocyanate is thoroughly tested for contaminating nonspecific endonuclease, exonuclease, and RNase activity.
2. Guanidine thiocyanate is a potent protein denaturant (stronger than guanidine HCl) often used in the isolation of intact ribon ucleic acid to eliminate RNase activity. RNase can recover activity after boiling, but is irreversibly inactivated in a 4 M solution of guanidine thiocyanate. Such solutions, to which the reducing agent b-mercaptoethanol is often added, are used to inactivate RNAse when isolating RNA from tissues that are rich in RNase, such as liver. Total nuclear and cytoplasmic RNA may be isolated this way. A protocol for extracting RNA with guanidine isothiocyanate has been published.
In the presence of guanidine thiocyanate, proteins dissolve readily, cellular structures disintegrate and nucleoproteins dissociate from nucleic acids, as protein secondary structure is lost.
3.Guanidine Thiocyanate is an organic compound with the chemical formula C2H6N4S and a molecular weight of 118.16. It is a potent protein denaturing agent and an effective nuclease inhibitor, commonly used as a nucleic acid protectant when extracting DNA and RNA from cells. Guanidine thiocyanate is a common component of nucleic acid extraction buffer, used to inactivate endogenous RNases, leading to denaturation of nuclear protein complexes.
4.Guanidine Thiocyanate is a compound with multiple functions, and its main application areas include:
Biopharmaceuticals and chemical reagents: As an aphrodisiac and strong denaturing agent, guanidine thiocyanate is used for denaturing and lysing cells, extracting RNA and DNA, and has no RNAse or DNAse activity.
Nucleic acid stability: As a nucleases inhibitor, guanidine thiocyanate can ensure the stability and purity of RNA, effectively inactivating potential infectious substances such as poliovirus.
PCR detection: used as a PCR inhibitor for qPCR detection of triple mitochondrial DNA (mtDNA).
5. RNA extraction: Guanidine thiocyanate is used as a strong denaturing agent to denature and lyse cells, extract RNA and DNA, and has no RNase or DNAse activity. It is particularly suitable for isolating RNA from tissues with high RNase activity.
Biochemical reagents: used as deliquents and strong denaturing agents in biochemical experiments for cell lysis and nucleic acid separation and extraction.
Pharmaceutical intermediate: Guanidine thiocyanate can be used as an intermediate in the pharmaceutical industry for the synthesis of other drugs or compounds.
Oil industry: In the oil industry, guanidine thiocyanate is used as a degreaser.
Daily chemical industry: used as a strong fat degrading agent in daily chemical industry, for cosmetics or other personal care products.
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